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Therapeutic Advances in Respiratory Disease
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Reviews

Review: Airway smooth muscle as a model for new investigative drugs in asthma

Michele Baroffio

Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

Emanuele Crimi

Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy

Vito Brusasco

Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy, vito.brusasco{at}unige.it

Bronchial asthma as such exists because airway smooth muscle (ASM) contracts excessively in response to various stimuli. After several decades during which research was mainly focused on airway inflammation, increasing attention is now being paid to a possible abnormal behaviour of ASM. Thus, ASM is regarded as a major target for anti-asthma treatments. This review first describes the mechanisms of ASM contraction and airway hyperresponsiveness, through cellular, animal and human models. The developments of new drugs targeting extra and/or intracellular pathway of ASM contraction are discussed.

Key Words: airway smooth muscle • asthma • airway hyperresponsiveness

Therapeutic Advances in Respiratory Disease, Vol. 2, No. 3, 129-139 (2008)
DOI: 10.1177/1753465808091154
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