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Therapeutic Advances in Respiratory Disease, Vol. 2, No. 3, 173-177 (2008)
DOI: 10.1177/1753465808092340

Reviews

Review: Stem cell therapy: the great promise in lung disease

Dario Siniscalco

Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, via S. Maria di Costantinopoli, 16-80138 Napoli, Italy, dariosin{at}uab.edu

Nikol Sullo

Department of Experimental Medicine - Section of Pharmacology "L. Donatelli"; Second University of Naples, Italy

Sabatino Maione

Department of Experimental Medicine - Section of Pharmacology "L. Donatelli"; Second University of Naples, Italy

Francesco Rossi

Department of Experimental Medicine - Section of Pharmacology "L. Donatelli"; Second University of Naples, Italy

Bruno D'Agostino

Department of Experimental Medicine - Section of Pharmacology "L. Donatelli"; Second University of Naples, Italy

Lung injuries are leading causes of morbidity and mortality worldwide. Pulmonary diseases such as asthma or chronic obstructive pulmonary disease characterized by loss of lung elasticity, small airway tethers, and luminal obstruction with inflammatory mucoid secretions, or idiopathic pulmonary fibrosis characterized by excessive matrix deposition and destruction of the normal lung architecture, have essentially symptomatic treatments and their management is costly to the health care system.

Regeneration of tissue by stem cells from endogenous, exogenous, and even genetically modified cells is a promising novel therapy. The use of adult stem cells to help with lung regeneration and repair could be a newer technology in clinical and regenerative medicine. In fact, different studies have shown that bone marrow progenitor cells contribute to repair and remodeling of lung in animal models of progressive pulmonary hypertension.

Therefore, lung stem cell biology may provide novel approaches to therapy and could represent a great promise for the future of molecular medicine. In fact, several diseases can be slowed or even blocked by stem cell transplantation.

Key Words: Stem cells • cell-based therapy • lung diseases • human


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