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Use of dry powder inhalers in acute exacerbations of asthma and COPD

Semeco AB, Angelholm, Ä Sweden, olof.selroos{at}telia.com

Lars Borgström

AstraZeneca R&D, Lund, Sweden

Jarl Ingelf

AstraZeneca R&D, Lund, Sweden

To investigate whether dry powder inhalers (DPIs) function in a constrained situation, a literature analysis was performed to evaluate the use of DPIs compared with established therapies in the treatment of acute asthma and COPD, irrespective of rapid-acting β₂-agonist used. The external databases Medline, Embase, Biosis and Current Contents and AstraZeneca's internal literature database Planet were searched up to April 2008. Only publications or congress abstracts describing clinical trials in patients treated at EDs or hospitals were considered, and then only those in which exacerbation severity (measured as FEV₁) were included. Fifteen clinical studies met these criteria; twelve in acute asthma and three in acute COPD. For acute asthma, eight studies were double-blind, randomised studies (six in adults and two in children), two were open-label studies (one in adults and one in children), and two were investigational (methacholine challenge) studies. For the acute COPD studies, one was double-blind and randomised, one was single-blind and randomised, and one was open-label. This review found that administration of fast-acting bronchodilators via DPIs, the majority of which were Turbuhaler, is effective during an asthma or COPD worsening. Our literature review finds that DPIs function in patients with acute asthma or COPD equally well as established therapies with other inhaler devices. Patients can therefore rely upon DPIs in the same way that they rely upon other inhaler devices.

Key Words: Dry powder inhaler • DPI • Turbuhaler • exacerbation • worsening • hospitalization • asthma • COPD

This version was published on April 1, 2009

Therapeutic Advances in Respiratory Disease, Vol. 3, No. 2, 81-91 (2009)
DOI: 10.1177/1753465809103737


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