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Therapeutic Advances in Respiratory Disease
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Sneeze reflex: facts and fiction

Murat Songu

Department of Otorhinolaryngology, Dr Behçet Uz Children's Hospital and Department of Otorhinolaryngology, Izmir Ataturk Research and Training Hospital, Izmir, Turkey songumurat{at}yahoo.com

Cemal Cingi

Department of Otorhinolaryngology, Osmangazi University Medical Faculty, Eskisehir, Turkey

Sneezing is a protective reflex, and is sometimes a sign of various medical conditions. Sneezing has been a remarkable sign throughout the history. In Asia and Europe, superstitions regarding sneezing extend through a wide range of races and countries, and it has an ominous significance. Although sneezing is a protective reflex response, little else is known about it. A sneeze (or sternutation) is expulsion of air from the lungs through the nose and mouth, most commonly caused by the irritation of the nasal mucosa. Sneezing can further be triggered through sudden exposure to bright light, a particularly full stomach and physical stimulants of the trigeminal nerve, as a result of central nervous system pathologies such as epilepsy, posterior inferior cerebellar artery syndrome or as a symptom of psychogenic pathologies. In this first comprehensive review of the sneeze reflex in the English literature, we aim to review the pathophysiology, etiology, diagnosis, treatment and complications of sneezing.

Key Words: sneeze • sneezing • reflex • sneeze reflex • trigeminal nerve

This version was published on June 1, 2009

Therapeutic Advances in Respiratory Disease, Vol. 3, No. 3, 131-141 (2009)
DOI: 10.1177/1753465809340571


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