SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Therapeutic Advances in Respiratory Disease
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1753465809345500v1
3/4/159    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Semfke, A.
Right arrow Articles by Gillissen, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Semfke, A.
Right arrow Articles by Gillissen, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Histologically proven isoniazid hepatoxicity in complicated tuberculous salpingitis

Almut Semfke

St George Medical Centre, Robert-Koch-Hospital, Leipzig, Germany

Cornelia Wackernagel

St George Medical Centre, Robert-Koch-Hospital, Leipzig, Germany

Hannelore Vier

St George Medical Centre, Robert-Koch-Hospital, Leipzig, Germany

Alexander Schütz

MVZ nuwamed Leipzig, Germany

Volker Wiechmann

Pathologie Elsapark, Leipzig, Germany

Adrian Gillissen

Institute of Pathology and Tumour Diagnostics, St George Medical Centre, Leipzig, Germany, adrian.gillissen{at}sanktgeorg.de

Isoniazid (INH) hepatic injury is histologically indistinguishable from viral hepatitis and is related to individual susceptibility of patients who hydrolyze the drug to isonicotinic acid at different rates. We here present a case initially involving a complaint of lower abdominal pain, which was diagnosed after a long diagnostic work-up as tuberculous salpingitis and which is rare in women in developed countries. A lack of pulmonary effects further delayed correct diagnosis of the underlying tuberculosis infection. Based on the clinical follow up and liver histology, INH-induced severe hepatoxicity, which further contributed to the abdominal symptoms, could be confirmed. After adaptation of the standard therapeutic regimen no further complications occurred.

Key Words: antibiotics • antitubercular agents • complications • INH • isoniazid • liver toxicity • salpingitis • side-effects • tuberculosis

This version was published on August 1, 2009

Therapeutic Advances in Respiratory Disease, Vol. 3, No. 4, 159-162 (2009)
DOI: 10.1177/1753465809345500
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement