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Therapeutic Advances in Respiratory Disease
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Sleep disorders and their management in patients with COPD

Amir Sharafkhaneh

Baylor College of Medicine, Sleep Disorders and Research Center, Michael E. DeBakey VA Medical Center, Houston TX, USA, amirs{at}bcm.tmc.edu

Gnananandh Jayaraman

Department of Medicine Baylor College of Medicine, Houston TX, USA

Thomas Kaleekal

Division of Pulmonary Critical care and Sleep Medicine, Medical College of Wisconsin, WI, USA

Hossein Sharafkhaneh

Department of Medicine Baylor College of Medicine, Houston TX, USA

Max Hirshkowitz

Department of Medicine, Baylor College of Medicine, Houston TX, USA, Medical Care Line, Michael E. DeBakey VA Medical Center, Houston TX, USA

Chronic obstructive pulmonary disease (COPD) is a prevalent progressive condition that adversely affects quality of life and sleep. Patients with COPD suffer from variety of sleep disorders including insomnia, sleep disordered breathing and restless leg syndrome. The sleep disorders in COPD patients may stem from poor control of primary disease or due to side effects of pharmacotherapy. Thus, optimization of COPD therapy is the main step in treating insomnia in these patients. Further, pharmacotherapy of sleep disorders may result in respiratory depression and related complications. Therefore, clear understanding of respiratory physiology during transition from wakefulness to sleep and during various stages of sleep plays an important role in therapies that are recommended in patients with significant airway obstruction. In this publication, we review respiratory physiology as it relates to sleep and discuss sleep disorders and their management in patients with COPD.

Key Words: airway obstruction • insomnia • sleep apnea

This version was published on December 1, 2009

Therapeutic Advances in Respiratory Disease, Vol. 3, No. 6, 309-318 (2009)
DOI: 10.1177/1753465809352198
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